The efficacy of CBD was evaluated using the light-dark box (LDB), elevated plus maze (EPM), tail suspension (TS), sucrose consumption (SC) and novel object recognition (NOR) tests. kg-1, p.o.) or its combination for 28 days.Once the model was established (4 weeks), mice received CBD (20 mg Methods: Effects of cannabidiol (CBD), alone or combined with sertraline (STR), were evaluated in male CD1 mice ( n = 48) exposed to an unpredictable chronic mild stress (UCMS) procedure. Introduction: This study aims to further characterize cannabidiol’s pharmacological and molecular profile as an antidepressant.
3Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain.2Research Network on Primary Addictions, Instituto de Salud Carlos III, MICINN and FEDER, Madrid, Spain.1Instituto de Neurociencias, Universidad Miguel Hernández, Alicante, Spain.María Salud García-Gutiérrez 1,2,3, Daniela Navarro 1,2,3, Amaya Austrich-Olivares 1 and Jorge Manzanares 1,2,3*
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